Warren and Katharine Schlinger Professor of Chemical Engineering
We have translated two nanoparticle-based therapeutics into the clinic for use as cancer therapeutics. These nanoarparticles have been investigated in 10 clinical trials. I will describe how we translated these nanoparticles from the laboratory at Caltech into clinical therapeutics. Lessons learned from these translational and clinical experiences are accelerating our current translational efforts with nanoparticle-based therapeutics for cancer. Additionally, we are in the process of creating nanoparticle-based therapeutics for treating diseases of the kidney and for crossing the blood brain barrier to provide therapeutics for treating maladies in the brain.
Ralph Adolphs (PhD ’93)
Bren Professor of Psychology and Neuroscience and Professor of Biology; Director of the Caltech Brain Imaging Center
My laboratory uses cognitive neuroscience approaches to understand human social behavior. This includes techniques such as brain imaging, eyetracking, and electrophysiology, and makes comparisons between several different patient populations. One focus has been to compare high-functioning people with autism to neurological patients who have focal lesions or disconnections of brain structures. Another focus has been, in collaboration with local neurosurgeons, to record activity from single cells in the brains of patients who have implanted depth electrodes. Together, these varied approaches are revealing to us how the brain processes information from faces, how we use such information to understand other people, and how this process can dysfunction in autism.
Richard L. and Dorothy M. Hayman Professor of Mechanical Engineering and Bioengineering
Spinal Cord Injury (SCI) affects nearly 1,250,000 people in the U.S. This talk focuses on a recent collaboration between Caltech, UCLA, and Univ. of Louisville aimed at developing new therapies for motor complete SCI based on multi-electrode arrays implanted over the lumbosacral spinal cord. SCI patients receiving this therapy have been able to stand independently and make some voluntary movements. They have made surprising gains in cardiovascular health as well as improved autonomic function such as bladder, bowel, and blood pressure regulation.
Pamela Björkman, Max Delbrück Professor of Biology and Investigator, Howard Hughes Medical Institute Research Laboratory, Caltech
Raymond Deshaies, Professor of Biology; Investigator, Howard Hughes Medical Institute
Axel Scherer, Bernard A. Neches Professor of Electrical Engineering, Applied Physics, and Physics; Co-Director, Kavli Nanoscience Institute
Shu-ou Shan, Professor of Chemistry