Class of 1965 reunion event for Caltech's Alumni Seminar Day and Reunion Weekend, "Remembering Richard P. Feynman", May 14, 2015. Featured speakers include Kip Thorne, Robbie Vogt, Ralph Leighton, Ted Jenkins. Produced in association with Caltech Academic Media Technologies.Read More…
Systems Medicine and Proactive P4 Medicine: Revolutionizing Health CareLee Hood (PhD ’68)
President, Institute for Systems Biology
We are at a tipping point in medicine, for the approaches of the old medicine are already beginning to be replaced by a medicine that is predictive, preventive, personalized, and participatory (P4). A major component of P4 medicine is the systems approach to disease, or systems medicine – employing global and comprehensive analyses of the disease process. Systems medicine is already creating powerful new genetic approaches to identifying disease genes; it is turning blood into a window for assessing health and disease in the individual; it is determining the genome sequences of tumors to identify targets for preexisting drugs; it is stratifying a disease into its different subtypes so that a proper impedance match against effective drugs can be achieved; it is beginning to develop entirely new, more rapid, and less expensive approaches to the creation of drugs; and it is beginning to assess wellness in individual patients.
I will discuss these revolutions in medicine with specific examples. I will also talk about some of the emerging technologies that are enabling P4 medicine – powerful sequencing machines for deciphering human genomes, a systems approach to blood diagnostics, new approaches to detecting proteins and the analyses of single cells.
P4 medicine is the convergence of systems medicine, big data analytics, and patient-activated social networks. I will discuss these latter features and predict where each of the four Ps will be in 10 years. I will then discuss the impact that P4 medicine will have on society, along with our efforts to bring P4 medicine to patients.
Viviana Gradinaru (BS ’05)
Assistant Professor of Biology
This is an exciting time, as it’s now becoming possible for neuronal circuits to be engineered to reverse pathological states like depression, addiction, and Parkinson’s disease, and to enhance mental performance. With the convergence of accumulating knowledge about brain circuits and technological advances in imaging and electrophysiology instrumentation, previously unimagined experiments are possible. Until recently, no available technology could cope with the tremendous variety of cell types in brain tissue. Now, optogenetics—a technology based on light-responsive proteins—can be used to probe brain circuitry, offering insight into both healthy and diseased brains. This lecture will describe the development of optogenetics and its applications and challenges.