Silicon Valley July Seminar

Silicon Valley July Seminar

This month, Lambertus Hesselink will discuss, “A Portable DNA Printer Based on Solid-Phase DNA Synthesis Platform.”

Thu
7/18/24
 
5:30 pm
 - 
Thu
7/18/24
 
7:00 pm
  
·  
Online
5:30 pm
 - 
7:00 pm
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Add to Calendar 2024-07-18 17:30 2024-07-18 19:00 America/Los_Angeles Silicon Valley July Seminar This month, Lambertus Hesselink will discuss, “A Portable DNA Printer Based on Solid-Phase DNA Synthesis Platform.” Online
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If you would like to attend, register in advance for this webinar. After the webinar, you are invited to talk to the speaker and mingle with other alumni in a post-webinar social via a Zoom meeting. We look forward to seeing you.

Peter Tong

A Portable DNA Printer Based on Solid-Phase DNA Synthesis Platform
by Lambertus Hesselink

Solid-phase synthesis (SPS) is a driving force for manufacturing biological molecules such as peptides, oligo nucleotides, and functionalized polymers which are instrumental in life science research, drug discovery, and personal therapeutics development. While the last decade has seen adoption of synthetic biology to fuel advances in diverse fields, the platforms for SPS have experienced little innovation. Conventional column and well-plate platforms suffer from synthesis errors due to unexposed solid support surface and impurities trapped within the matrix, limiting yield and product length.

To address this, we introduce a novel lab-on-a-chip platform employing light-orchestrated microdroplet (picoliter volume) reactors for SPS. Our platform can precisely encapsulate/decapsulate individual solid supports (microbeads ~5um) with corresponding reagent microdroplets. This ensures uniform reagent exposure, which reduces error rate and improves the yield rate. Furthermore, the platform can reduce reagent consumption and waste by almost a million-fold. Using our platform, we have successfully demonstrated on-chip DNA synthesis reaction, which can lead to a commercially viable portable DNA printer.

Bert Hesselink is Professor of Electrical Engineering and Applied Physics, by courtesy, at Stanford. His group focuses on curiosity driven fundamental light-matter interactions, with applications in 3-D imaging, digital optical data storage and display, among others. He has presented over 270 keynote and invited presentations at scientific meetings; organized over 80 scientific meetings; and published over 500 papers in scientific journals, and over 15 book chapters. And he was an editor of Applied Optics, Applied Scientific Research, and IEEE Transaction on Visualization.

Bert has over 100 issued and pending patent applications worldwide. He pioneered 3-D optical data storage technology, demonstrating world-record performance in 2000. He built the first Internet controlled laboratory in 1998. His group pioneered the field of topological matrix and tensor visualization in the middle 1990’s. He founded three startups, consulted for Fortune 100 corporations worldwide, co-designed the Astronaut Memorial, was a member of the Hubble Space Telescope Committee, and a member of the Air Force Scientific Advisory Board.

Among other honors, Bert is a Member of the National Academy of Inventors, the Royal Dutch Academy of Arts and Sciences, and Fellow of the OSA and SPIE; and he studied at Caltech as a Fulbright scholar!

Our Alumni Volunteers

The following alumni work together to serve you:
Avni Gandhi, Dave Adler, Jane Frommer, Mike Klein, Susan Huynh, and Peter Tong.

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