Pioneer of "Directed Evolution" Wins Lifetime Achievement Award

Frances Arnold, the Dick and Barbara Dickinson Professor of Chemical Engineering, Bioengineering and Biochemistry, is being honored with the Society of Women Engineers' 2017 Achievement Award. The society's highest award, the Achievement Award is given out every year to a "woman who has made an outstanding technical contribution for at least 20 years in a field of engineering."

In the early 1990s, Arnold pioneered the so-called "directed evolution" method for engineering new and better enzymes. In this technique, biological enzymes are "bred" in the lab to have desired traits. The method is widely used to make enzymes for consumer products and medical diagnostics.

Directed evolution also leads to greener ways of manufacturing products, including pharmaceuticals, biofuels, and even blue jeans. The enzymes are not harmful to the environment and often replace toxic chemicals.

"Evolution is the most powerful engineering method in the world, and we should make use of it to find new, biological solutions to problems," says Arnold.

"Receiving this award is such an honor, given all the tremendous contributions women engineers have made to improving our health, our environment, and our prospects for a sustainable future," says Arnold.

Recently, Arnold and her colleagues used directed evolution to persuade bacteria to create silicon-carbon bonds—something only chemists had achieved before. The research suggests that nature can quickly adapt to perform new types of chemistry. What's more, the finding has applications for manufacturing products with silicon-carbon bonds, from lubricants to pharmaceuticals, in more environmentally friendly ways.

In 2016, Arnold was the first woman to receive the Millennium Technology Prize, granted by the Technology Academy Finland, and she was the first woman to receive the 2011 Charles Stark Draper Prize from the National Academy of Engineering. Arnold is also the first woman elected to all three branches of the National Academies—the National Academy of Engineering (2000), the Institute of Medicine (2004), and the National Academy of Sciences (2008). She was inducted into the National Inventors Hall of Fame in 2014 and received the National Medal of Technology and Innovation in 2013. She recently won the 2017 Sackler Prize from the National Academy of Sciences.

Arnold received her undergraduate degree in mechanical and aerospace engineering at Princeton University in 1979 and her graduate degree in chemical engineering from UC Berkeley in 1985. She arrived at Caltech as a visiting associate in 1986 and became an assistant professor in 1987, associate professor in 1992, professor in 1996, and Dick and Barbara Dickinson Professor of Chemical Engineering, Bioengineering and Biochemistry in 2000. She became the director of the Donna and Benjamin M. Rosen Bioengineering Centerat Caltech in 2013.

Written by Whitney Clavin